CYP2E1 catalyzes the metabolic activation of tobacco-specific N-nitrosamines, including 4- (methylnitrosamino) - 1- (3-pyridyl) - 1-butanone.
An Rsa I polymorphism, witch is located in the 5'-flanking region of the CYP2E1 gene, has been found to affect the transcriptional regulation of the gene, resulting in different expression levels of the mRNA among individuals.
In order to investigate an association between the Rsa I polymorphism and lung cancer susceptibility, the genotype distribution among 316 lung cancer patients was compared with that in 503 healthy controls.
No statistically significant association was found between the Rsa I polymorphism and an increased risk of lung cancer, even though histological types of lung cancer, cigarette smoking and alcohol consumption were taken into account.
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Homme, Polymorphisme, Gène, Facteur risque, Nitrosamine, Cytochrome P450, Japon, Asie, Epidémiologie, Bronche pathologie, Poumon pathologie, Appareil respiratoire pathologie, Gène CYP2E1
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Human, Polymorphism, Gene, Risk factor, Nitrosamine, Cytochrome P450, Japan, Asia, Epidemiology, Bronchus disease, Lung disease, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0316831
Code Inist : 002B11A. Création : 01/03/1996.