Occurrence of ankylosing spondylitis in a nationwide series of twins.
To obtain information on the rate of concordance for ankylosing spondylitis (AS) in a population-based series of twins.
AS cases were identified by record linkage of the population-based Finnish Twin Cohort and the nationwide registry for fully reimbursed medications.
A clinical examination was performed to establish concordance for AS.
There were 6 monozygotic (MZ) pairs and 20 dizygotic (DZ) pairs with at least 1 member affected by AS.
Three MZ pairs and 3 DZ pairs were concordant for the disease.
All affected subjects were HLA-B27 positive
The pairwise concordance rate was 50% in MZ twins and 20% in HLA-B27 positive DZ twins (95% confidence intervals 11.8-88.2% and 4.3% - 48.1%, respectively).
These results indicate that AS disease expression is largely, but not entirely, genetically based, with a gene or genes other than B27 probably playing a role.
Mots-clés Pascal : Spondylarthrite ankylosante, Homme, Epidémiologie, Finlande, Europe, Déterminisme génétique, Etude familiale, Jumeau, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire
Mots-clés Pascal anglais : Ankylosing spondylitis, Human, Epidemiology, Finland, Europe, Genetic inheritance, Family study, Twin, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0287392
Code Inist : 002B15D. Création : 01/03/1996.