Decrease of incidence of toxic nodular goitre in a region of Switzerland after full correction of mild iodine deficiency.
In 1980 the iodide content of salt was increased in Switzerland from 7.5 to 15 mg/kg.
This raised the mean urinary iodine excretion from 90 (indicating mild iodine deficiency) to 150 mug/g creatinine.
We examined whether this public health measure was followed by a change of the incidence of hyperthyroidsm in a defined catchment area of 109 000 persons.
Except for a 27% rise in the first year of the new salt, the total incidence of hyperthyroidism declined steadily to reach 44% of the control level in 1988/89.
This was due to a decrease mostly of toxic nodular goitre (minus 73%), less so of Graves'disease (minus 33%). We conclude that conection of mild iodine deficiency has beneficial effects on the incidence of hyperthyroidism, contrary to what is seen initially after correction of severe deficiency.
Mots-clés Pascal : Déficit, Iode, Suisse, Europe, Epidémiologie, Goitre nodulaire, Goitre endémique, Incidence, Homme, Endocrinopathie, Thyroïde pathologie
Mots-clés Pascal anglais : Deficiency, Iodine, Switzerland, Europe, Epidemiology, Nodular goiter, Endemic goiter, Incidence, Human, Endocrinopathy, Thyroid diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0286006
Code Inist : 002B21A01. Création : 01/03/1996.