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  1. Decrease of incidence of toxic nodular goitre in a region of Switzerland after full correction of mild iodine deficiency.

    Article - En anglais

    In 1980 the iodide content of salt was increased in Switzerland from 7.5 to 15 mg/kg.

    This raised the mean urinary iodine excretion from 90 (indicating mild iodine deficiency) to 150 mug/g creatinine.

    We examined whether this public health measure was followed by a change of the incidence of hyperthyroidsm in a defined catchment area of 109 000 persons.

    Except for a 27% rise in the first year of the new salt, the total incidence of hyperthyroidism declined steadily to reach 44% of the control level in 1988/89.

    This was due to a decrease mostly of toxic nodular goitre (minus 73%), less so of Graves'disease (minus 33%). We conclude that conection of mild iodine deficiency has beneficial effects on the incidence of hyperthyroidism, contrary to what is seen initially after correction of severe deficiency.

    Mots-clés Pascal : Déficit, Iode, Suisse, Europe, Epidémiologie, Goitre nodulaire, Goitre endémique, Incidence, Homme, Endocrinopathie, Thyroïde pathologie

    Mots-clés Pascal anglais : Deficiency, Iodine, Switzerland, Europe, Epidemiology, Nodular goiter, Endemic goiter, Incidence, Human, Endocrinopathy, Thyroid diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0286006

    Code Inist : 002B21A01. Création : 01/03/1996.