An excess mortality for violence (suicides and injuries) has been observed following the use of cholesterol-lowering drugs.
It has been suggested that low cholesterol is associated with depression by modifying the serotonin metabolism.
In this paper, a new hypothesis concerning the association among serum lipids, depression, and atherosclerosis is proposed.
The hypothesis is based on epidemiologic evidence concerning serum lipids, depression, violent deaths, and atherosclerosis.
It is also based on previous results concerning a cytokine, interleukin-2.
Recent observations indicate that interleukin-2 has an important role in lipid metabolism, depression, and atherosclerosis.
Mots-clés Pascal : Suicide, Etat dépressif, Trouble humeur, Homme, Epidémiologie, Cholestérol, Lipide, Interleukine 2, Cytokine, Athérosclérose, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Suicide, Depression, Mood disorder, Human, Epidemiology, Cholesterol, Lipids, Interleukin 2, Cytokine, Atherosclerosis, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0272960
Code Inist : 002B18C11. Création : 01/03/1996.