Does renal impairment protect from gout ?
To test whether renal impairment protects from the development of gout.
We conducted a retrospective cohort study in which 40 hyperuricemic patients (serum uric acid>0.54 mM/l) with renal impairment (serum creatinine>200 muM/l) and 40 equally hyperuricemic patients with normal renal function (serum creatinine<120 muM/l) were given a telephone questionnaire eliciting a history of gout, its pattern and severity, and other features of medical and family history.
There was no significant difference among the prevalence of gout (relative risk 1.1, confidence interval 0.73-1.61), the pattern and severity of gout, and the presence of tophi between the 2 groups.
A positive family history of gout was significantly increased in the patients with gouty arthritis (p<0.05).
Renal impairment does not protect from gout.
There may be a familial factor in the development of gout that is independent from the familial tendency for hyperuricemia.
Mots-clés Pascal : Insuffisance rénale, Chronique, Homme, Goutte(pathologie), Protection, Prévalence, Association, Epidémiologie, Microcristal, Urique acide, Appareil urinaire pathologie, Rein pathologie, Métabolisme pathologie, Hyperuricémie, Système ostéoarticulaire pathologie, Arthropathie
Mots-clés Pascal anglais : Renal failure, Chronic, Human, Gout, Protection, Prevalence, Association, Epidemiology, Microcrystal, Uric acid, Urinary system disease, Renal disease, Metabolic diseases, Hyperuricemia, Diseases of the osteoarticular system, Arthropathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0262030
Code Inist : 002B15I. Création : 01/03/1996.