Impact of liver disease and hepatitis infections on allogeneic bone marrow transplantation in Europe : a survey from the European Bone Marrow Transplantation (EBMT) Group-Infectious Diseases Working Party.
This survey investigated allogeneic bone marrow transplantation (BMT) policy in European BMT units by questionnaire, in relation to pre-transplant liver disease.
It also assessed diagnostic standards for viral hepatitis infections and their prevalence in BMT candidates.
Sixty-three EBMT centers from 22 countries participated in the survey.
Median pre-transplant prevalences of HBsAg and anti-HCV positivity were 3.5% (range 0-15%) and 5% (range 0-45%), respectively.
Forty-six (73%) centers adopt the policy of cancelling or postponing BMT in patients with ALT abnormalities but in four of these centers, BMT is not delayed when progressive disease or acute leukemia is present.
In 17 institutions (27%) BMT was reported to be carried out irrespective of transaminase values.
Mots-clés Pascal : Homogreffe, Moelle osseuse, Transfusion, Homme, Traitement, Complication, Hépatite virale, Virose, Infection, Epidémiologie, Prévalence, Diagnostic, Méthodologie, Etude multicentrique, Echelon international, Europe, Appareil digestif pathologie, Foie pathologie, Greffe, Maladie veinoocclusive
Mots-clés Pascal anglais : Homograft, Bone marrow, Transfusion, Human, Treatment, Complication, Viral hepatitis, Viral disease, Infection, Epidemiology, Prevalence, Diagnosis, Methodology, Multicenter study, International scope, Europe, Digestive diseases, Hepatic disease, Graft, Venoocclusive disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0255705
Code Inist : 002B27D02. Création : 01/03/1996.