Presentation and dissent : the risk of lung cancer in nonsmokers in the United States and its reported association with environmental tobacco smoke. Author's reply.
Is environmental tobacco smoke (ETS) causally related to lung cancer ?
In this study, 29 case-control and three cohort studies involving exposed and unexposed female smokers (as defined herein, an exposed individual is a never-smoker married to a smoker and an unexposed individual is a never-smoker married to a never-smoker) and nine case-control and two cohort studies involving exposed and unexposed male smokers, in which presence or absence of lung cancer is the specified outcome, are reviewed.
It is pointed out that any attempt to make inferences toward such a causal relationship must account for the fundamental differences in these studies, which took place on three continents over 15 years and involved many differences in individual study design as well as in study subjects.
Since this has largely not been done, the only conclusion that sensibly can be drawn from these studies is that the conclusion of a causal relationship is currently not supported by the data.
This is certainly true when an attempt is made to apply a world-wide risk ratio to the U.S. population, as was done in the U.S. Surgeon Generals report (1986) (U.S. Surgeon General.
The Health Consequences of Involuntary Smoking.
U.S. Department of Health and Human Sciences, Rockville, MD, 1986 ).
Mots-clés Pascal : Tabagisme passif, Non fumeur, Tumeur maligne, Bronchopulmonaire, Homme, Epidémiologie, Métaanalyse, Etats Unis, Amérique du Nord, Amérique, Asie, Europe, Poumon pathologie, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Passive smoking, Non smoker, Malignant tumor, Bronchopulmonary, Human, Epidemiology, Metaanalysis, United States, North America, America, Asia, Europe, Lung disease, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0255224
Code Inist : 002B03E. Création : 01/03/1996.