CD4+T-cell number at the time of acquired immunodeficiency syndrome.
In this article, the authors adapt and extend the methodology of Phillips (Phillips et al.
J Acquir Immune Defic Syndr 1992 ; 5 : 148-52) to estimate the distribution of CD4+T-cell number at the time of acquired immunodeficiency syndrome (AIDS) and to estimate the correlation between CD4+T-cell number at AIDS and CD4+T-cell number prior to human immunodeficiency virus infection.
Using data from the Los Angeles portion of the Multicenter AIDS Cohort Study, the authors find that the median CD4+T-cell count at the time of AIDS is 67 cells/mm3 with a 95% confidence interval of 58-84.
The 5th and 95th percentiles of the distribution are 8 and 284, respectively.
The authors estimate the correlation between the CD4+T-cell number at the time of AIDS and the CD4+T-cell number prior to human immunodeficiency virus infection to be 0.71 with a 95% confidence interval of 0.21-0.94.
This very high correlation is suggestive of biologic hypotheses concerning possible control of the circulating CD4+T-cell number.
The high correlation can also be useful in determining when to start prophylactic treatment.
Mots-clés Pascal : SIDA, Virose, Infection, Lymphocyte T, Numération, Survie, Analyse statistique, Méthode statistique, Homme, Evolution, Epidémiologie, Immunopathologie, Immunodéficit, Antigène CD4
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, T-Lymphocyte, Numeration, Survival, Statistical analysis, Statistical method, Human, Evolution, Epidemiology, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0254938
Code Inist : 002B06D01. Création : 01/03/1996.