In order to elucidate the dose-response relationship between ingested inorganic arsenic and internal cancers, a total or 263 patients with blackroot disease and 2293 healthy residents in the endemic area or arseniasis were recruited and followed up for 7 years.
The information on consumption or high-arsenic artesian well water, sociodemographic characteristics, life-style and dietary habits, and personal and family history of cancers was obtained through standardized interviews.
The occurrence of internal cancers among study subjects was determined through annual health examinations, home visit personal interviews, household registration data checks, and national death certification and cancer registry profile linkages.
A dose-response relationship was observed between the long-term arsenic exposure from drinking artesian well water and the incidence of lung cancer, bladder cancer, and cancers of all sites combined after adjustment for age, sex, and cigarette smoking through Cox's proportional hazards regression analysis.
Blackfoot disease patients had a significantly increased cancer incidence after adjustment for cumulative arsenic exposure.
Mots-clés Pascal : Arsenic, Composé minéral, Voie orale, Toxicité, Carcinogène, Tumeur maligne, Tumeur solide, Homme, Relation dose réponse, Etude longitudinale, Long terme, Epidémiologie, Polluant, Environnement, Taiwan, Asie
Mots-clés Pascal anglais : Arsenic, Inorganic compound, Oral administration, Toxicity, Carcinogen, Malignant tumor, Solid tumor, Human, Dose activity relation, Follow up study, Long term, Epidemiology, Pollutant, Environment, Taiwan, Asia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0254672
Code Inist : 002B04E02. Création : 01/03/1996.