Colorectal cancer is caused by environmental exposures and genetic predisposition.
However, little is known of hereditary factors that influence development of common, non-Mendelian forms of this cancer.
Interactions among carcinogen exposure, hereditary variants of enzymes involved in carcinogen metabolism, and other host factors may play a role.
Genetic polymorphisms of carcinogen metabolism, such as the glutathione transferase M1 (GSTM1) null genotype, are thus possibly related to cancer risk.
The GSTM1 enzyme detoxifes mutagens formed from polycyclic aromatic hydrocarbons which are found in tobacco smoke.
We analyzed GSTM1 genotypes and smoking among 488 controls and 446 individuals with a first time diagnosis of colorectal adenoma which are precursors to cancer.
Subjects were from two Kaiser Permanente sigmoidoscopy clinics in southern California.
We observed no overall effect of the GSTM1 null genotype on the risk for colorectal adenomas (odds ratio, 0.85 ; 95% confidence interval=0.65-1.10).
The odds ratio for smokers with the null genotype was 2.07 (95% confidence interval=1.14-3.77) when compared to « never smokers » without the null genotype.
Using this same reference group, the odds ratio for smokers without the null genotype was 1.73 (95% confidence interval=1.03-2.90).
These two odds ratios were not significantly different (P=0.30).
Mots-clés Pascal : Tabagisme, Tabac, Toxicité, Adénome, Rectum, Côlon, Prévalence, Carcinogenèse, Facteur risque, Homme, Polymorphisme, Glutathione transferase, Transferases, Enzyme, Isozyme, Génotype, Epidémiologie moléculaire, Tumeur bénigne, Tumeur maligne, Intestin pathologie, Appareil digestif pathologie, Californie, Etats Unis, Amérique du Nord, Amérique, Glutathione transferase M1
Mots-clés Pascal anglais : Tobacco smoking, Tobacco, Toxicity, Adenoma, Rectum, Colon, Prevalence, Carcinogenesis, Risk factor, Human, Polymorphism, Glutathione transferase, Transferases, Enzyme, Isozyme, Genotype, Molecular epidemiology, Benign neoplasm, Malignant tumor, Intestinal disease, Digestive diseases, California, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0254633
Code Inist : 002B13B01. Création : 01/03/1996.