logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Helicobacter pylori infection, serum pepsinogen level and gastric cancer : a case-control study in Japan.

    Article - En anglais

    We conducted a case-control study to evaluate the effect of Helicobacter pylori (HP) infection on the risk of gastric cancer in Tokyo, Japan.

    The sera at the time of diagnosis from 282 gastric cancer cases and 767 sex-and age-matched cancer-free controls were tested for the presence of anti-HP IgG antibody (HM-CAP ELISA kit) and serum pepsinogen (PG) level (PG I and PG II Riabead).

    No significant association was observed in all sets [matched odds ratio (OR)=1.04,95% confidence interval : 0.73-1.49]. In subgroup analyses, however, an association was suggested to females [OR=1.57], a younger population (<50 years) [OR=1.86], early cancer [OR=1.53] and small cancer (<40 mm) [OR=1.55]. Furthermore, we observed a tendency for odds ratios to decrease with an increase in age or cancer growth (depth of tumor invasion and tumor size).

    Considering that the spontaneous disappearance of HP due to extended mucosal atrophy may lead to these decreasing odds ratios, we applied the conditional logistic model adjusted for the PG I/II ratio as a measure of atrophic gastritis.

    This analysis showed a positive association with HP infection in all sets [OR=1.69 ; 1.01 2.81], distal cancer [OR=1.88 ; 1.07-3.31] and intestinal-type cancer [OR=3.76 ; 1.39 10.18]. We concluded that the risk of cancer associated with HP infection may be underestimated in studies with cross-sectional exposure because of spontaneous disappearance of HP due to extended mucosal atrophy.

    Mots-clés Pascal : Tumeur maligne, Estomac, Facteur risque, Epidémiologie, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Pepsinogène, Sérum, Japon, Asie, Homme, Estomac pathologie, Appareil digestif pathologie, Etude cas témoin

    Mots-clés Pascal anglais : Malignant tumor, Stomach, Risk factor, Epidemiology, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Pepsinogen, Serum, Japan, Asia, Human, Gastric disease, Digestive diseases, Case control study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0248703

    Code Inist : 002B13B01. Création : 01/03/1996.